Micky van de Ven Double Halts The Toffees' Run at Brand New Stadium
Micky van de Ven became the first backline player to net twice in a English top-flight match for Tottenham since Jan Vertonghen in March 2013.
At a glance
Micky Van de Ven nods into the net two times in opening period
The home side's defender has equalizer disallowed after video check
Senegalese midfielder nets third in 89th minute
This loss is the Merseyside club's first at Hill Dickinson Stadium
Micky van de Ven found the net on two occasions as Spurs extended their winning streak on the road in the Premier League and delivered Everton their first defeat at Hill Dickinson Stadium.
The Toffees were unbeaten in their last five matches at their new ground at Bramley-Moore Dock, having departed their historic home behind after 133 years at the end of the previous campaign.
But Tottenham's leader Van de Ven pounced on two occasions from set-pieces in the first half to put their impressive record at risk, and they were unable to mount a comeback before Pape Matar Sarr - set up by ex-Everton forward the Brazilian - headed home a final goal to put the game to bed.
The Everton defender believed he had equalized the scores five minutes after the defender's opener, directing a powerful header past the Spurs keeper from an Everton corner.
The Portuguese striker, in the meantime, missed a number of opportunities, while Vicario made a succession of fine saves to guarantee the London club went five matches on the road without defeat in the English top flight.
But the VAR stepped in, instructing Craig Pawson to check the score on the screen and the referee ruled that Jack Grealish and the attacker were in offside positions and had interfered with the Tottenham goalkeeper.
This victory elevates Thomas Frank's team into third place in the Premier League, five points off north London rivals and table-toppers the Gunners.
Everton stay in 14th position and are half a dozen points ahead of the drop zone.
Spurs breakdown: The defender fulfils role at both ends of pitch
Following a drab weekday performance in the Champions League against the French side, where they mustered a only attempts on goal, Frank opted for Randal Kolo Muani in attack instead of former Toffees player the Brazilian.
The summer signing was unable to make much of an impact before being substituted for Richarlison after 60 minutes on the field, but it turns out he wasn't needed in the end.
Defender Van de Ven transformed into an offensive threat to be reckoned with.
Tottenham's opening strike came from a cleverly executed set-piece play, with the midfielder heading the ball back across the six-yard box for an free the defender to head home.
And the captain - filling in as captain in the Argentine's unavailability - notched his next goal in first-half stoppage time as he rose above Jordan Pickford to head home.
The Dutchman was equally outstanding in defence, combining effectively with Kevin Danso as the duo handled excellently with the 34 crosses thrown their way by Everton.
Toffees breakdown: Toffees lacking striker's instinct
Everton's new home had been a happy hunting ground, but it seems the freshness may have worn off slightly and fans headed to the gates after the midfielder's final goal for Tottenham.
The break in Everton's unbeaten home run will not be a massive concern for David Moyes, but their attacking woes will be.
The forward and Thierno Barry - the Toffees' pair of recognised strikers - had netted only a single goal between them before Sunday's match.
And they were unable to contribute to that miserable tally on a wet and gloomy evening on in Liverpool.
The striker's performance was summed up when he opted to bicycle-kick a clear chance from near the goal, despite having space and time to reposition for a simpler shot that would have tested Vicario.
Barry, too, was unable to influence the game after replacing Beto in the second half.
It was not for a shortage of opportunity. Most of Everton's attacks came through the winger and the forward, who tirelessly delivered threatening balls into the Spurs penalty area.
Upcoming fixtures for these two sides?
Everton: The team travel to the Stadium of Light in the top flight on Monday, 3 November at 20:00 GMT.
Spurs: Spurs go to Newcastle's ground on late October for their fourth-round League Cup match against Newcastle.